Thanks to actor Jack Nicholson, Steenburgen was cast in her first film, Goin' South, in 1978. Her role in Melvin and Howard launched her to stardom two years later, and she took home a Best Supporting Actress Oscar and a Golden Globe for her beguiling performance. Among Steenburgen's other noteworthy movies are Cross Creek (1983), Back to the Future III (1990), Philadelphia (1996), Nixon (1995) and the 2003 comedy hit Elf.
Despite her busy work schedule, Steenburgen devotes time to ecological and human rights issues.