Bassett took on a string of roles playing real-life famous women, including Jackson family matriarch Katherine in the TV movie The Jacksons: An American Dream (1992), Betty Shabazz in Malcolm X (1992) and Tina Turner in What's Love Got to Do with It (1993), for which Bassett received a Best Actress Oscar nomination. She also played Rosa Parks in the 2002 television movie The Rosa Parks Story.
Bassett has proved she can deftly adapt to science fiction films (1995's Strange Days and 1997's Contact), dramas (1995's Waiting to Exhale and 1998's How Stella Got Her Groove Back), comedies (2004's Mr. 3000) and action films (2005's Mr. and Mrs. Smith).