Barrymore began his prolific career on stage and built a reputation as a serious actor before transitioning to film, copping an Oscar nod for directing Madame X (1929) and winning the statuette for his brilliant performance in A Free Soul (1931). Known for playing lovable grumps, he starred in numerous movies throughout the 1930s and '40s, including Grand Hotel (1932), Dinner at Eight (1933), You Can't Take It with You (1938) and a series of Doctor Kildare films. But he's perhaps best remembered for his portrayal of villainous miser Mr. Potter in director Frank Capra's It's a Wonderful Life (1946).
On Nov. 15, 1954, Barrymore died of a heart attack at age 76.