When writer Jay McInerney declared Sevigny the new "It" girl in an article for The New Yorker, a string of roles in indie films followed. Her supporting turn as the troubled girlfriend of Hilary Swank in Boys Don't Cry (1999) netted Sevigny an Academy Award nomination
Among Sevigny's other notable screen credits are The Last Days of Disco (1998), Shattered Glass (2003) and Melinda and Melinda (2004). Her television work includes playing the second wife of a polygamist on the HBO series "Big Love," a role that earned her a Golden Globe award in 2009.