At the height of her Broadway fame, Ryan left the theater world to pursue work in TV and feature films, landing a recurring role on the hit HBO series "The Wire" (2003-08) before scoring high-profile supporting turns in War of the Worlds (2005) and Capote (2005).
But it was Ryan's raw portrayal of a negligent mother in Gone Baby Gone (2007) that truly caught Hollywood's attention and earned her Oscar and Golden Globe nods for Best Supporting Actress, among other accolades.