Epps quickly made his mark in Hollywood playing opposite gangsta rapper Tupac Shakur in 1992's Juice, a powerful drama about four Harlem teens. Other noteworthy films for Epps include director John Singleton's Higher Learning (1995), Scream 2 (1997), The Wood (1999), In Too Deep (with LL Cool J), Love and Basketball (2000), Alfie (2004) and Against the Ropes (costarring Meg Ryan).
Also a musician, Epps is a member of the rap group Wolfpak, which he formed with his brother in 1991.