Moving to the United States to attend college in the early 1980s, Elwes eventually abandoned his studies to pursue acting full time. It wasn't long before he began to land roles in films on both sides of the Atlantic, but his international breakthrough didn't come until 1987, when he was cast as the swashbuckling romantic lead in The Princess Bride.
Since then, Elwes has moved easily from comedy to drama and from supporting roles to star turns in movies such as Hot Shots!, The Crush, Cradle Will Rock, Shadow of the Vampire, Ella Enchanted and Saw (2004).