Dukakis made her film debut in Lilith (1964) and, five years later, played Dustin Hoffman's mother in John and Mary. While earning two "Obies" for her off-Broadway work, she made small film appearances in the 1970s and '80s (Made for Each Other, Death Wish, The Wanderers and The Idolmaker).
After Moonstruck, Dukakis enjoyed prominent roles in Steel Magnolias, Dad, Look Who's Talking, The Cemetery Club and television's "Tales of the City." She continues to teach drama at New York University.