After logging supporting roles on TV and in movies such as Blue Collar (1978), Begley landed the part he's still most closely associated with: the earnest but awkward Dr. Victor Ehrlich on TV's "St. Elsewhere." Six Emmy nods and more TV shows followed, including recurring roles on "Six Feet Under" (in which he played Ruth Fisher's on-again, off-again paramour Hiram Gunderson) and "Arrested Development."
Notable films for Begley include This Is Spinal Tap, The Accidental Tourist, Auto Focus and A Mighty Wind (2003).