When, at the ripe old age of 30, Russo's modeling career started to fade, she took time off to study acting, and in 1987 was cast on the TV series "Sable." Her film debut came in 1989 when she was cast opposite Tom Berenger in Major League.
Since then, Russo has proved she can more than hold her own with the toughest guys, playing strong women in films such as One Good Cop, In the Line of Fire, Outbreak, Get Shorty, Tin Cup, the 1999 remake of The Thomas Crown Affair (opposite Pierce Brosnan) and 2005's Yours, Mine and Ours.