Peet soon made her entry into feature films (Animal Room, 1995) and TV (an episode of "Law & Order"), and her acting career was off and running. A role in the romantic comedy One Fine Day followed, and Peet has since been featured in increasingly prominent roles, finally achieving leading-lady status with 2000's The Whole Nine Yards.
More recently, Peet has achieved notice playing Jeff Goldblum's heroin-addicted mistress in Igby Goes Down, Jack Nicholson's much younger lover in Something's Gotta Give and the wife of an oil analyst in Syriana.