Privileged Chihuahua Chloe (voiced by Drew Barrymore) rides in style in her owner's designer handbag -- until the pampered pooch gets lost during a Mexican vacation and must find her way home with help from some newfound canine friends. Salma Hayek, George Lopez, Edward James Olmos, Cheech Marin and Andy Garcia also lend their voices to the cast of this whimsical live-action comedy directed by Raja Gosnell.