When Preston Tylk (Luke Wilson) finds out that his wife, Emily (Mili Avital), has been cheating on him, he storms out the house and returns later to find she's been strangled to death. Distraught, Preston immediately assumes the murderer is Emily's lover (Norman Reedus) and sets out to find him. But a terrible mistake on Preston's part soon gets him framed for not one but two murders and pulls him into a deadly game of betrayal and revenge.