In this sequel to the original Cheaper by the Dozen, Lillian Gilbreth (Myrna Loy) must now care for her 12 kids without the help of her husband, who has just died. Now the sole wage earner, she has trouble finding a job, but soon ends up working for Sam Harper (Edward Arnold). Also causing strain are the fast-growing children, including daughter Ann (Jeanne Crain), whose budding romance with young doctor Bob (Jeffrey Hunter) is heating up.

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